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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CANX
All Species:
51.21
Human Site:
Y379
Identified Species:
75.11
UniProt:
P27824
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P27824
NP_001019820.1
592
67568
Y379
P
V
I
D
N
P
N
Y
K
G
K
W
K
P
P
Chimpanzee
Pan troglodytes
XP_001151304
592
67554
Y379
P
M
I
D
N
P
N
Y
K
G
K
W
K
P
P
Rhesus Macaque
Macaca mulatta
XP_001101429
592
67582
Y379
P
M
I
D
N
P
N
Y
K
G
K
W
K
P
P
Dog
Lupus familis
XP_533285
610
69806
Y368
P
M
I
D
N
P
K
Y
K
G
V
W
R
P
P
Cat
Felis silvestris
Mouse
Mus musculus
P35564
591
67259
Y380
P
M
I
D
N
P
N
Y
K
G
K
W
K
P
P
Rat
Rattus norvegicus
P35565
591
67236
Y380
P
M
I
D
N
P
N
Y
K
G
K
W
K
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506871
598
67609
Y382
P
M
I
D
N
P
N
Y
K
G
K
W
K
S
P
Chicken
Gallus gallus
NP_001025791
599
68090
Y380
P
M
I
D
N
P
N
Y
K
G
K
W
K
P
P
Frog
Xenopus laevis
NP_001080326
611
69964
Y391
P
T
I
D
N
P
M
Y
K
G
K
W
K
P
P
Zebra Danio
Brachydanio rerio
NP_998613
600
67856
Y387
P
M
I
D
N
P
N
Y
K
G
K
W
K
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29413
406
46790
F271
P
M
I
D
N
P
E
F
K
G
E
W
Q
P
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34652
619
69189
Y371
P
T
I
K
N
P
K
Y
K
G
K
W
I
R
P
Sea Urchin
Strong. purpuratus
XP_791226
591
66512
Y373
P
M
V
P
N
P
E
Y
K
G
K
W
K
A
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9SP22
420
47921
K285
Y
K
G
P
W
K
Q
K
K
I
K
N
P
N
Y
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P29402
530
60468
Y326
P
M
K
R
N
P
A
Y
K
G
K
W
S
S
P
Baker's Yeast
Sacchar. cerevisiae
P27825
502
56949
Y351
G
L
I
N
N
A
K
Y
K
G
P
G
E
L
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.6
59.1
N.A.
93
93.5
N.A.
85.7
82.8
78.2
70.8
N.A.
31.7
N.A.
40.5
53.7
Protein Similarity:
100
99.8
99.4
75.2
N.A.
96.6
97.4
N.A.
93.1
90.8
86.2
84.1
N.A.
44.7
N.A.
58.9
69.7
P-Site Identity:
100
93.3
93.3
73.3
N.A.
93.3
93.3
N.A.
86.6
93.3
86.6
86.6
N.A.
60
N.A.
66.6
66.6
P-Site Similarity:
100
100
100
86.6
N.A.
100
100
N.A.
93.3
100
86.6
93.3
N.A.
86.6
N.A.
66.6
80
Percent
Protein Identity:
N.A.
29.3
N.A.
40
25.6
N.A.
Protein Similarity:
N.A.
44.4
N.A.
53.5
41.2
N.A.
P-Site Identity:
N.A.
13.3
N.A.
60
33.3
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
66.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
7
0
0
0
0
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
69
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
13
0
0
0
7
0
7
0
0
% E
% Phe:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% F
% Gly:
7
0
7
0
0
0
0
0
0
94
0
7
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
82
0
0
0
0
0
0
7
0
0
7
0
0
% I
% Lys:
0
7
7
7
0
7
19
7
100
0
82
0
63
0
7
% K
% Leu:
0
7
0
0
0
0
0
0
0
0
0
0
0
7
0
% L
% Met:
0
69
0
0
0
0
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
94
0
50
0
0
0
0
7
0
7
7
% N
% Pro:
88
0
0
13
0
88
0
0
0
0
7
0
7
57
82
% P
% Gln:
0
0
0
0
0
0
7
0
0
0
0
0
7
0
0
% Q
% Arg:
0
0
0
7
0
0
0
0
0
0
0
0
7
7
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
7
19
0
% S
% Thr:
0
13
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
7
7
0
0
0
0
0
0
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
7
0
0
0
0
0
0
88
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
88
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _